• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    VALVE CONTAINER ASSEMBLY The present invention relates to a valve container assembly (10) comprising a container (12) for containing a fluid, the container (12) extending in an axial direction and being provided with at least at least one ventilation opening (12a) at a front end and at least one dispensing opening (12b). The valve container assembly (10) also comprising a valve (14) arranged in the container (12) and a plunger element (20) axially disposed behind the valve (14), the plunger element (20) being axially movable in the container (12) and defining a first volume (22) in the container (12) between the plunger element (20), and the valve (14), where the plunger element (20) is configured to increase the pressure of a fluid in the first volume (22) by axial movement in relation to the valve (14). The valve (14) comprises a permanent seal (16) that forms a fluidic seal between the at least one vent (12a) and the first volume (22). It is a resilient seal (18) which is axially behind the said permanent seal (16) and is movable between a seal configuration and an open configuration. In the seal configuration, the resilient seal (18) forms a fluid seal with the container (12) between at least one dispensing opening (12b) (...).
    公开号:BR112014031228B1
    申请号:R112014031228-1
    申请日:2013-06-14
    公开日:2020-11-10
    发明作者:Matt Ekman；Ian Anderson
    申请人:Consort Medical Plc；
    IPC主号:
    专利说明:

    TECHNICAL FIELD
    [001] The present invention relates to a container assembly with a valve. Specifically, the present invention relates to a valve container assembly that has a self-opening valve. BACKGROUND OF THE INVENTION
    [002] Document GB2400040 (Bespac pic) describes a closing member for a container, such as a vial, that seeks to facilitate the distribution of a measured dose of medication, for example, in a nasal dispenser. In particular, Document GB2400040 describes a container or bottle for a fluid, the container comprising a housing that defines an internal part for storing the fluid and a closing member. The closing member comprises a body and at least one resilient projection to seal in a storage condition an outlet of the enclosure, in which by means of an increase in pressure from the inner part of the container to at least one resilient projection is deflected to accommodate the flow of fluid through the outlet. In a described embodiment, the closing member has a sealing part that seals the closing member to the container around the circumference of the closing member and the pressure within the container increases by displacement of the closing member to the container. In another described embodiment, the container is part of a dispensing apparatus. In this embodiment, however, the sealing part is separated from the closing member and forms a plug that can be moved within the container to increase the pressure therein.
    [003] An objective of the present invention is to provide a set of recipient with an alternative valve for dispensing a fluid. SUMMARY OF THE INVENTION
    [004] According to a first aspect of the present invention there is provided a container assembly with valve comprising; a container for containing a fluid, the container extending in an axial direction and having at least one vent opening at a front end and at least one dispensing opening; a valve arranged in the container; and a plunger element disposed axially behind the valve, the plunger element being axially movable in the container and defining a first volume in the container between the plunger element and the valve, the plunger element is configured to increase the pressure of a fluid in the first volume by axial movement with respect to the valve; where the valve comprises: a permanent seal that forms a fluidic seal between the at least one vent and the first volume; and a resilient seal which is axially behind the said permanent seal and is movable between a seal configuration and an open configuration; wherein in the sealing configuration the resilient seal forms a fluid seal with the container between at least one dispensing opening and the sealing part; at least in an axial position of the valve in the container when the resilient seal is in the open configuration the sealing part is fluidly connected to at least one dispensing opening; and wherein the resilient seal is movable from the seal configuration to the open configuration by fluid pressure in the first volume exceeding a predetermined pressure limit.
    [005] The at least one axial position of the valve in the container in which the first volume is fluidly connected to at least one dispensing opening when the resilient seal is in the open configuration may include the most advanced axial position of the valve in the container.
    [006] The resilient seal may comprise one or more flexible elements, wherein the one or more flexible elements may extend partially and circularly around said valve and the remainder of the valve forms a seal with the container circumferentially around said one or more flexible elements. Alternatively, one or more flexible elements may extend fully circumferentially around said valve.
    [007] The resilient seal can comprise at least two flexible elements, wherein the at least two flexible elements can be axially aligned with each other.
    [008] The permanent seal may comprise at least one flange projecting out of said valve around the entire perimeter of the valve, said at least one flange sealing against said container. The permanent seal may comprise at least two flanges projecting out of said valve around the entire perimeter of the valve, wherein the at least two flanges are arranged in axial alignment with each other.
    [009] The plunger element may comprise a plunger stopper.
    [010] The valve may comprise elastomeric material.
    [011] The valve container can be a main packaging to be used as part of a dispensing device.
    [012] The valve container can be sized and configured to be inserted into a human nasal cavity.
    [013] In accordance with a second aspect of the present invention, a dispensing apparatus is provided which includes: a valve container assembly according to the first aspect of the present invention; and an energy source for moving the plunger element and a valve-filled container assembly so as to expel fluid from the first volume through at least one dispensing opening.
    [014] Said container set with valve can be sized and configured to be inserted into a human nasal cavity.
    [015] The energy source can include a fluid propellant that boils to create a gas pressure to move the plunger element.
    [016] The fluidic propellant may include or consist of a hydrofluoralkane (HFA).
    [017] The container with valve can be fixed in such a way that it can be released from the remainder of the dispensing device, in which the releasable coupling can be a bayonet fitting. Said bayonet fitting may be the container assembly with valve and an aisle of the dispensing apparatus.
    [018] In accordance with a third aspect of the present invention, there is provided a kit comprising a dispensing apparatus according to the second aspect of the present invention, and a plurality of container assemblies with an additional valve, where each of the plurality of assemblies container with additional valve is individually fixed so that it is released to the remainder of the dispensing apparatus.
    [019] In accordance with a fourth aspect of the present invention, a method of assembling a container assembly with a valve is provided, comprising the steps of: providing a container that extends in an axial direction and has at least one opening ventilation at a front end and at least one dispensing apparatus that is axially behind the ventilation opening; inserting a valve in the container, where the valve comprises a permanent seal and a resilient seal that is axially behind the permanent seal; move the valve axially to the front end of the container and allow air between the front end of the container and the valve to exit the container through the ventilation opening; fill the container behind the valve with fluid; insert a plunger element axially behind the fluid so that the fluid is disposed between the valve and the plunger element. The fluid can be a medicine. DESCRIPTION OF THE DRAWINGS
    [020] The modalities of the invention are also described below with reference to the accompanying drawings, in which: Figures 1A to 1C are a cross-sectional view illustrating a valve container assembly according to one embodiment of the present invention, in several stages DETAILED DESCRIPTION
    [021] Figures 1A to 1C illustrate various stages of operation of a container assembly with valve 10 according to an embodiment of the present invention. The valve container set 10 can be any container set suitable for containing and dispensing a measured fluid dose such as a medicament, but not limited to a syringe, vial or nasal spray. The valve container assembly 10 comprises a container 12 which preferably has a circular or rounded cross-section (for example, cylindrical or conical), a valve 14 arranged in the container 12 and a piston element 20 arranged in the container 12. The container 12 extends along a longitudinal geometric axis between a front end and a rear end. The container 12 has a vent opening 12a at the front end and has a rear opening 12c at the rear end. Additionally, the container 12 is provided with a dispensing opening 12b between the ventilation opening 12a and the rear opening 12c, which for example, axially behind the ventilation opening 12a. In the embodiment illustrated in the Figures, the dispensing opening 12b is a radial hole in the container 12. In fact, where the dispensing opening 12b is axially behind the dispensing opening 12a, the dispensing apparatus 12b will be extended in a radial direction or by least has a radial component along its length. Although the embodiment described in the Figures includes a single ventilation opening 12a and a single dispensing opening 12b, in alternative embodiments, there may be more than one ventilation opening 12a and / or more than one dispensing opening 12b. The one or more ventilation opening 12a and / or one or more dispensing opening 12b can take any suitable shape, such as, for example, a hole, slit or nozzle.
    [022] Throughout this application, reference to "front" or front "or the like is referring to the front end of the container 12 where the vent 12a is arranged. References to "axial" or similar denote directions parallel to the longitudinal geometric axis of the container 12. References to "rear" "rear" or similar are in reference to the direction opposite to the "forward" direction along an axial path.
    [023] Valve 14 is arranged in container 12 at or near the front end of container 12 and includes a permanent seal 16 that forms a fluid tight seal with the inside of the container around the periphery of valve 14. In one embodiment preferred, valve 14 is formed from an elastomeric material so that the sealing effect provided by the permanent seal 16 between the valve 14 and the container 12 is realized due to the elastomeric nature of the valve 14, and therefore the permanent seal 16.
    [024] Axially behind the permanent seal 16, the valve 14 has a resilient seal 18 that is formed from a pair of axially aligned flexible elements 18a, 18b that extend radially from the valve 14 and extend around the entire periphery of the valve 14. The width (i.e. the radial extension of the valve 14 between the permanent seal 16 and the resilient seal 18 is smaller than the width of the permanent seal 16 so that the part of the valve 14 between the permanent seal 16 and the resilient seal 18 does not contact container 12. This formation results in a ring formed between valve 14 and container 12 between permanent seal 16 and resilient seal 18. Although in the embodiment illustrated in the Figures it has two flexible elements 18a, 18b, in alternative embodiments, the resilient seal 18 may include a single flexible element or three flexible elements, or more.
    [025] In alternative embodiments, the resilient seal 18 does not extend around the entire periphery (circumference) of valve 14, where the additional permanent seal seals valve 14 to container 12 in areas where the resilient seal 18 does not extend . In these alternative embodiments, an axial channel, instead of a ring formed between the valve and the container 12 axially between the permanent seal 16 and the resilient seal 18.
    [026] As described in more detail below, the resilient seal 18 is movable between a seal configuration (as shown in Figure 1A) and an open configuration (as shown in Figure 1B), where the seal configuration, the resilient seal 18 fluidly seals valve 14 to container 12, and in the open configuration, resilient seal 18 does not fluidly seal valve 14 to container 12.
    [027] Between the valve 14 and the plunger element 20, a first volume 22 is defined which can contain a fluid such as a fluidic medicine.
    [028] In a particularly preferable embodiment, the dispensing opening 12b is axially spaced behind the ventilation opening 12a by an amount that is less than the axial distance between the permanent seal 16 and the resilient seal 18, and greater than the axial thickness of the permanent seal 16. In this preferred embodiment, when the valve 14 is arranged in its axial position backwards in the container 12, the permanent seal 16 seals the ventilation opening 12a and the dispensing opening 12b is axially disposed between the permanent seal 16 and the resilient seal 18.
    [029] When the resilient seal 18 is in the seal configuration, it provides a fluid seal with the container 12 between the first volume 22 and the dispensing opening 12b in order to prevent any fluid from escaping in the first volume 22 of the container 12 through the dispensing opening 12b.
    [030] When the resilient seal 18 is in the open configuration, the first volume 22 is in fluid communication with the atmosphere through the dispensing opening 12b, subject to the same axial position as valve 14 in container 12. In fact, for the first volume is fluidly connected to the dispensing opening 12b, the dispensing opening 12b must be in fluid communication with the ring (that is, be axially aligned with it) formed between the permanent seal 16 and the resilient seal 18 of the valve 14. In the In the case where a channel instead of a ring is formed between the permanent seal 16 and the resilient seal 18, the dispensing opening 12b needs to be rotationally aligned and axially aligned with the channel in order to establish fluid communication between the channel and opening dispensation 12b.
    [031] In the preferred embodiment where the dispensing opening 12b is axially disposed between the permanent seal 16 and the resilient seal 18 when the valve 14 is disposed in its most advanced axial position in the container 12, the first volume 22 will be fluidly connected to the opening dispensing 12b when valve 14 is in its most forward axial position in container 12 and resilient seal 18 is in its open configuration. In the case where a channel instead of a ring is formed between the permanent seal 16 and the resilient seal 18, restraining elements or other suitable devices may be present to ensure that the valve 14 is rotated correctly in a way that the channel is in fluid communication with the dispensing opening 12b.
    [032] The resilient seal 18 is moved from the seal configuration to the open configuration when a force incident on the resilient seal 13 exceeds a predetermined limit. Such a force will arise when the fluid pressure of a fluid action on the resilient seal 18 exceeds a predetermined limit. For example, if the first volume 22 was filled with a fluid (such as a fluidic medicine), then the resilient seal 18 will move from the seal configuration to the open configuration when the fluid pressure has exceeded a predetermined limit. When the pressure exceeds the predetermined limit, the flexible elements 18s, 18b of the resilient seal 18 flex or deflect away from the container 12 and open a fluid path that allows the fluid to bypass the resilient seal 18. Alternative components can forming the resilient seal 18 in place of the flexible elements 18a, 18b that deform, skew or otherwise move to open a fluid path between the valve 14 and the container 12 by applying a predetermined force. In the embodiment illustrated in Figure 18, the flexible elements 18a, 18b are shown to be flexed or tilted in an advanced direction, as might be expected as a result of the fluid pressure in the first volume 22 that exceeds the predetermined pressure limit.
    [033] In both the seal configuration and the open configuration of the resilient seal 18, the permanent seal 16 remains in place and maintains a seal between the valve 14 and the container 12 axially in front of the resilient seal 18. Therefore, the ventilation opening 12a is always fluidly sealed from the first volume 22.
    [034] Figure 1A shows the container assembly with valve 10 prior to activation. The first volume 22 contains fluid and the resilient seal 16 is in its seal configuration. To drive the device for dispensing the fluid from the container 12, an axially advanced force is applied to the plunger element 20 to increase the pressure in the fluid above the predetermined limit. The axially advanced force can be applied directly by a user (for example, via a plunger rod), or the user can trigger an energy source that then exerts or causes another element to apply an axially advanced force to the plunger element 20.
    [035] In the embodiment illustrated in figure 1A, valve 14 is always in its most advanced axial position in container 12, so that the front end of container 12 prevents any further axially advanced movement of valve 14 with respect to container 12. Therefore , the valve 14 remains axially fixed to the medium that is actuated by the force applied to the piston element 20 due to its nature of fluid that cannot be compressed. The resilient seal 18 is therefore fulfilled by the fluid which is above a predetermined limit, and the resilient seal 18 moves from the seal configuration to the open configuration.
    [036] When in the open configuration, the additional axially advanced movement of the plunger element 20 with respect to the fixed valve 14 causes the fluid to flow out of the first volume through the dispensing opening 12b as described by the arrows 24 in Figure 1B.
    [037] The continued axially advanced force of the plunger element 20 with respect to the fixed valve 14 causes all fluid in the first volume 22 to be expelled through the dispensing opening 12b, and the first volume 22 is reduced substantially to zero, as illustrated in Figure 1C. At that point, the dispensing operation is completed.
    [038] The plunger element 20 can be accessed through the open rear end 12c of the container 12 and can additionally include a plunger rod or the like to facilitate its axial movement within the container 12. In a preferred embodiment, however, the element plunger 20 is driven by a gas pressure, for example, provided by a boiling propellant to provide adequate gas pressure to move the plunger element 20. Among other possibilities within the scope of the present invention, suitable impellers include or consist entirely of hydrofluoralkanes (HFA). The present invention is particularly suitable for the delivery of viscous drugs.
    [039] The container assembly 10 can be a main package that is used as part of a dispensing apparatus that additionally includes an energy source to automatically move the plunger element 20 to dispense fluid. In a particularly preferred embodiment, the container 12 is shaped and configured to be inserted into a human nasal cavity to deliver a dose of medicine measured therein. Alternatively, the container set can be configured to dispense a dose of medicine measured in other areas of the body, which may or may not be a cavity.
    [040] In an alternative or also preferred embodiment, several valve container sets are provided for use as part of a reusable dispensing apparatus, of which valve container sets 10 are the only components that can be used. discarded. In this arrangement, each of the valve container sets 10 is attached to the remainder of the dispensing apparatus so that it can be released individually, so that when one of the medicine from the valve container set 10 has been dispensed, that set of container with valve 10 can be removed from the dispensing apparatus and replaced with another set of container with valve 10 to dispense an additional dose of medication.
    [041] Container assemblies with valve 10 can be fixed in such a way that they can be released to the remainder of the dispensing apparatus by a bayonet fitting or other suitable mechanism that allows a secure adjustment, but a user friendly removal and replacement. Other suitable connections include, but are not limited to, a screw fitting, pressure arrangement or fitting.
    [042] Valve container sets 10 may be supplied in a package that may have individually sealed compartments (for example, a blister package) to contain individual valve container sets 10 separately from each other.
    [043] In one embodiment, container sets with valve 10 can be supplied with or connected to an applicator, where the user takes the applicator to connect the container set with valve 10 to the remainder of the dispensing device and then removes the applicator , leaving the container assembly with valve 10 attached to the remainder of the dispensing apparatus. The valve assembly 10 may be attached to the dispensing apparatus by any suitable securing mechanism, including, but not limited to, a bayonet fitting, a screw adjustment arrangement, a fitting arrangement or a pressure arrangement.
    [044] The dispensing apparatus may include a shrapnel box or other suitable supply of propellant as a source of energy for moving the plunger element 20 to dispense a dose of fluid from the container 12. The shrapnel box or other propellant supply it can contain enough propellant to energize a single dispensing action (i.e., the fluid of a single container set with valve 10), or it can contain enough propellant to energize a plurality of dispensing actions 9that is, fluid from more than one set with valve 10).
    [045] In accordance with an aspect of the present invention, a method of filling the container with a valve that includes the initial step of inserting the valve 14 into the container 12 with the permanent seal 16 that enters the rear opening 12c of the container 12 first of all that the permanent seal 16 is advanced axially from the resilient seal 18 in the container 12. Then, the valve 14 is moved axially towards the front end of the container 12. The action is allowed because the air trapped between the valve 14 and the front end from the container 12 it can exit the container 12 through the ventilation opening 12a. With valve 14 in its most forward axial position, a fluid, such as a fluidic medicine, can be introduced into container 12 axially behind valve 14. Once the fluid has been introduced, plunger element 20 can be inserted in the container 12 axially behind the fluid so that the fluid is disposed between the valve 14 and the plunger element 20 (i.e., in the first volume 22). Such a method of assembly relies on the presence of the ventilation opening 12a to allow the transfer of the valve 14 in the container 12 to its most advanced axial position in it.
    [046] Throughout the description and claims of this application, the words "comprises" and "contains" and their variations mean "including, but not limited to," and they are not intended to (and do not) exclude other halves, additives, components, integers or steps. Throughout the description and claims of the present application, the singular encompasses the plural unless the context requires otherwise. In particular, where the indefinite article is used, the report must be understood as contemplating plurality as well as singularity, unless the context requires otherwise.
    [047] The aspects, integers, characteristics, compounds, halves or chemical groups described in combination with a particular aspect, modality or example of the invention should be understood as applicable to any other aspect, modality or example described herein, unless they are incompatible with the same. All aspects described in this report (including any of the claims, summary and attached drawings), and / or all steps of any method or process so described, may be combined in any combination, except combinations where at least part of such aspects and / or stages are mutually exclusive. The invention is not restricted to the details of any of the aforementioned modalities. The invention extends to any new invention, or any new combination, of the aspects described in this report (including any of the claims, summary and attached drawings), or to any new invention, or any new combination, of the steps or any method or process so described.
    [048] The reader's attention is directed to all papers and documents that are filed simultaneously with or prior to this report with respect to that request and that are open to public inspection with that report, and the contents and such papers and documents are incorporated herein by reference.
    权利要求:
    Claims (21)
    [0001]
    1. Valve container assembly (10), comprising: a container (12) for containing a fluid, the container (12) extending in an axial direction and having at least one vent opening (12a) in one front end and at least one dispensing opening (12b); a valve (14) arranged on the container (12); and a plunger element (20) disposed axially behind the valve (14), the plunger element (20) being axially movable in the container (12) and defining a first volume (22) in the container (12) between the piston (20) and valve (14), where the piston element (20) is configured to increase the pressure of a fluid in the first volume (22) by axial movement with respect to the valve (14); wherein the valve (14) comprises: a permanent seal (16) that forms a fluidic seal with an interior of the container (12) around a periphery of the valve (14) between at least one vent (12a) and the first volume (22); and a resilient seal (18) which is axially behind the said permanent seal (16) and is movable between a seal configuration and an open configuration; wherein, in the seal configuration, the resilient seal (18) forms a fluidic seal with the container (12) between at least one dispensing opening (12b) and the first volume (22); in at least one axial position of the valve (14) in the container (12) when the resilient seal (18) is in the open configuration, the first volume (22) is fluidly connected to at least one dispensing opening (12b); CHARACTERIZED by the fact that the resilient seal (18) comprises one or more flexible elements (18a, 18b) configured to flex over the fluid pressure in the first volume (22) that exceeds a predetermined pressure limit in order to move the resilient seal (18) from the seal configuration to the open configuration to allow fluid to bypass the resilient seal (18); and wherein the at least one axial position of the valve (14) in the container (12) in which the first volume (22) is fluidly connected to at least one dispensing opening (12b) when the resilient seal (18) is in the open configuration it includes the most advanced axial position of the valve (14) in the container (12).
    [0002]
    2. Valve container assembly (10) according to claim 1, CHARACTERIZED by the fact that said one or more flexible elements (18a, 18b) extend partially in a circular way around said valve (14) and the remainder of the valve (14) forms a seal with the container (12) circularly around said one or more flexible elements (18a, 18b).
    [0003]
    3. Valve container assembly (10) according to claim 1, CHARACTERIZED by the fact that said one or more flexible elements (18a, 18b) extend entirely in a circular manner around said valve (14) .
    [0004]
    4. Valve container assembly (10) according to any one of claims 1 to 3, CHARACTERIZED by the fact that the resilient seal (18) comprises at least two flexible elements (18a, 18b).
    [0005]
    5. Valve container set (10) according to claim 4, CHARACTERIZED by the fact that at least two flexible elements (18a, 18b) are axially aligned with each other.
    [0006]
    6. Valve container assembly (10) according to any one of claims 1 to 5, CHARACTERIZED by the fact that the permanent seal (16) comprises at least one flange that protrudes from said valve (14) in around the entire perimeter of the valve (14), said at least one flange sealing against said container (12).
    [0007]
    7. Valve container assembly (10) according to claim 6, CHARACTERIZED by the fact that the permanent seal (16) comprises at least two flanges that protrude from said valve (14) around the entire perimeter of the valve (14), in which the at least two flanges are arranged in axial alignment with each other.
    [0008]
    Valve container assembly (10) according to any one of claims 1 to 7, CHARACTERIZED by the fact that the plunger element (20) comprises a plunger stopper.
    [0009]
    9. Valve container assembly (10) according to any one of claims 1 to 8, CHARACTERIZED by the fact that said valve (14) comprises elastomeric material.
    [0010]
    10. Valve container set (10) according to any one of claims 1 to 9, CHARACTERIZED by the fact that the valve container (12) is a primary package for use as part of a dispensing apparatus.
    [0011]
    11. Valve container set (10) according to any one of claims 1 to 10, CHARACTERIZED by the fact that the valve container (12) is sized and configured to be inserted into a human nasal cavity.
    [0012]
    12. Dispensing apparatus, CHARACTERIZED by the fact that it includes: a set of container with valve (10) as defined in any one of claims 1 to 9; and an energy source for moving the plunger element (20) of the valve container assembly (10) so as to expel fluid from the first volume (22) through at least one dispensing opening (12b).
    [0013]
    13. Dispensing apparatus according to claim 12, CHARACTERIZED by the fact that said container set with valve (10) is sized and configured to be inserted into a human nasal cavity.
    [0014]
    14. Dispensing apparatus according to claim 12 or 13, CHARACTERIZED by the fact that said energy source includes a fluid propellant which boils to create a gas pressure to move the plunger element (20).
    [0015]
    15. Dispensing apparatus according to claim 14, CHARACTERIZED by the fact that said fluidic propellant includes or consists of a hydrofluoralkane (HFA).
    [0016]
    16. Dispensing apparatus according to any one of claims 12 to 15, CHARACTERIZED by the fact that the container with valve (12) is fixed so as to be released to the remainder of the dispensing apparatus.
    [0017]
    17. Dispensing apparatus according to claim 16, CHARACTERIZED by the fact that said releasable coupling is a bayonet fitting.
    [0018]
    18. Dispensing apparatus according to claim 17, CHARACTERIZED by the fact that said bayonet fitting is between the valve container assembly (10) and a dispensing apparatus housing.
    [0019]
    19. Kit comprising a dispensing apparatus, as defined in any of claims 16 to 18, and a plurality of container assemblies with additional valve (10), CHARACTERIZED in that each of the plurality of container assemblies with valve (10) ) is fixed individually so that it can be released to the remainder of the dispensing apparatus.
    [0020]
    20. Method of assembling a container assembly with valve (10), CHARACTERIZED by the fact that it comprises the steps of: providing a container (12) that extends in an axial direction and has at least one ventilation opening (12a) at a front end and at least one dispensing opening (12b) that is axially behind the ventilation opening (12a); inserting a valve (14) in the container, where the valve (14) comprises a permanent seal (16) and a resilient seal (18) which is axially behind the permanent seal (16); move the valve (14) axially towards the front end of the container (12) and allow air between the front end of the container (12) and the valve (14) to exit the container (12) through the vent (12a) ; fill the container (12) axially behind the valve (14) with fluid; insert a plunger element (20) axially behind the fluid so that the fluid is disposed between the valve (14) and the plunger element (20).
    [0021]
    21. Method, according to claim 20, CHARACTERIZED by the fact that the fluid is a medicine.
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    同族专利:
    公开号 | 公开日
    NO2861354T3|2018-08-25|
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    DK2861354T3|2018-04-30|
    GB2503028A|2013-12-18|
    PT2861354T|2018-04-23|
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    法律状态:
    2018-12-04| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2020-03-17| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2020-09-01| B09A| Decision: intention to grant|
    2020-11-10| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/06/2013, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    GB1210654.8A|GB2503028B|2012-06-15|2012-06-15|Valved container assembly|
    GB1210654.8|2012-06-15|
    PCT/GB2013/051557|WO2013186568A1|2012-06-15|2013-06-14|Valved container assembly|
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